Solitary For Mac

Solitary For Mac Rating: 9,0/10 2521 reviews
Published online 2015 Oct 26. doi: 10.1186/s13256-015-0723-4

The classic card game of Solitaire, for Mac OS X. What do you need to know about free software? Publisher's Description. From Matt Gray: The classic card game of Solitaire, for Mac OS X. Aug 03, 2017  Mac DeMarco: Solitary Man For DeMarco, songwriting is an activity best experienced alone. Written By Jeff Terich // August 3, 2017. Second attempt at making movies I do not own any part of this song. 'Solitary Man' is a song that was written and composed by American musician Neil Diamond, who himself initially recorded the song for Bang Records in February 1966. It has since been covered many times by such artists as Billy Joe Royal, B.J. Thomas, Jay and the Americans, T. Sheppard, Gianni Morandi, The Sidewinders, Chris Isaak, Johnny Cash, Johnny Rivers, HIM, Crooked Fingers, Cliff. ‎ Solitary takes contestants to the threshold of tolerance by challenging their individual psychological and physical endurance. It's a mind game where the ultimate nemesis lives in the mind of the contestant — and they never meet one another. The only company available to players in conf.

PMID: 26503229

Jan 27, 2011  NOW 72 deliciously delightful solitaire games for your Mac and daily challenges! The new games and daily challenges are available as an In-App-Purchase on Mac OS X 10.8 or later. Designed by a Mac and Solitaire loving Mom and Daughter, Full Deck Solitaire is a beautiful card game with an easy to use user interface. 123 Free Solitaire is a 100% free high-quality solitaire games collection. Download and play now for free: Spider solitaire, FreeCell, Klondike and many other exciting solitaire games. 123 Free Solitaire features a winning layout, fast game play, rich sounds, extensive options, Undo and Redo feature and quality help. Each game has more than nine trillion (9,999,999,999,999) possible shuffles.

This article has been cited by other articles in PMC.

Abstract

Introduction

Mycobacterium avium complex (MAC) lung disease presenting as a solitary pulmonary nodule (MAC-SPN) is often asymptomatic, is more common in middle to old age, and mimics lung cancer or tuberculoma. We report herein a case of MAC-SPN in an immunocompetent young adult patient, presenting with persistent chest pain and a subacutely progressive nodule with high intense 18F-fluorodeoxyglucose uptake. Histological examination of resected specimens revealed pleurisy, which is a rare finding of MAC-SPN.

Case presentation

A 36-year-old Japanese male presented with chest pain and a subacutely progressive pulmonary nodule. Positron emission tomography-computed tomography showed high intense 18F-fluorodeoxyglucose uptake in the nodule. Owing to his continuous chest pain and subacutely progressive nodules, wedge resection was performed using video-assisted thoracoscopic surgery. Histological examination revealed an epithelioid granuloma and pleurisy, and the lung tissue culture was positive for mycobacteria identified as M. avium.

Conclusion

This is the first report of MAC-SPN occurring with persistent chest pain, suggesting that MAC should be considered in the differential diagnosis of a solitary pulmonary nodule, even for patients who experience persistent chest pain. As in the present case, surgical resection with video-assisted thoracoscopic surgery is a reasonable approach to the diagnosis and treatment of MAC-SPN with possible malignancy, especially as MAC can be diagnosed using resected lung tissue culture with histological confirmation.

Keywords: Mycobacterium avium complex lung disease, solitary pulmonary nodule, 18F-fluorodeoxyglucose, positron emission tomography

Introduction

Mycobacterium avium complex (MAC) lung disease commonly presents as upper lobe fibrocavitary or nodular bronchiectatic forms of pulmonary disease and occasionally presents as a solitary pulmonary nodule (MAC-SPN) []. MAC-SPN is often asymptomatic, is more common in middle to old age, and mimics lung cancer or tuberculoma [–]. We report a case of MAC-SPN in an immunocompetent young adult patient, presenting with persistent chest pain and a subacutely progressive nodule with high intense 18F-fluorodeoxyglucose (FDG) uptake. Histological examination of resected specimens revealed pleurisy, which is a rare finding of MAC-SPN.

Case presentation

A 36-year-old Japanese male was referred to our hospital because of persistent chest pain and a subacutely progressive pulmonary nodule. Four weeks prior to his referral to our hospital, he began to experience chest pain that increased in severity on inspiration. He visited a private hospital the following day. He had no family or personal history of nontuberculous or pulmonary disease. Chest computed tomography (CT) showed an irregularly shaped solitary nodule in the periphery of the left lower lobe with microcalcifications and pleural indentation. On CT at a follow-up appointment 2 weeks after the initial consultation, the nodule was enlarged (Fig. 1a, ,b).b). To diagnose the subacutely progressive pulmonary nodule, a CT-guided lung biopsy was performed in the private hospital. The histological examination of the biopsy specimens revealed granulomatous inflammation with atypical cells of various sizes. One week later, the patient was referred to our hospital. Although we intended to clarify the origin of the atypical cells and rule out malignancy, the specimen volume was insufficient for further investigation.

Remove the Hard Disk (IDE) and add a new drive.Choose 'Hard Disk SATA Use an existing virtual disk.' Add the hard driveNow it's time to add our virtual drive. For example, if you have 8GB RAM as we do, go for 4GB on the virtual machine.In the end, we press Finish. Disk imager for mac Click on 'Edit virtual machine settings.'

Computed tomography scan of the chest. a Chest computed tomography showed an irregularly shaped solitary nodule in the periphery of the left lower lobe, with microcalcifications (arrow) and pleural indentation. b After 2 weeks, the nodules became enlarged, around which ground glass opacity appeared

He reported no history of smoking, foreign travel, eating crab or boar or deer meat, or contact with patients with active pulmonary tuberculosis. The results of his physical examinations, including vital signs and consciousness, were normal. The laboratory data, including lymphocyte count, C-reactive protein, procalcitonin, gamma globulin, tumor markers, antineutrophil cytoplasmic antibodies, anti-HIV antibody, β-D-glucan, aspergillus antigen, cryptococcus antigen, Interferon-Gamma Release Assay (T-SPOT.TB®), and antibody to Paragonimus westermani or P. miyazaki, were unremarkable. Two weeks after the referral, positron emission tomography (PET)-CT showed intense FDG uptake in the nodules, with a maximum standard uptake value (SUV) of 13.94 (Fig. 2).

Positron emission tomography-computed tomography scan of the chest. A positron emission tomography-computed tomography scan showed intense 18F-fluorodeoxyglucose uptake in the nodular shadow with a maximum standard uptake value of 13.9

Owing to his continuous chest pain and subacutely progressive nodules, which could not be diagnosed using CT-guided lung biopsy, wedge resection via video-assisted thoracoscopic surgery was performed in the left lower lobe. The histological examination revealed an epithelioid granuloma, with caseating necrosis and calcification, and pleurisy over the visceral pleurae (Fig. 3ad). Although a smear test of the resected lung tissue was negative, the patient was initially diagnosed with tuberculosis based on the results of the histological examination. Antituberculous therapy was initiated with isoniazid, rifampicin, ethambutol, and pyrazinamide. Because the patient presented with severe skin eruptions and high fever 2 weeks after initiation of the antituberculous therapy, we paused the treatment. One week later, the lung tissue culture was positive for mycobacteria identified as Mycobacterium avium via DNA-DNA hybridization. His chest pain disappeared almost simultaneously. Anti-interferon-γ autoantibodies were negative. We plan to initiate anti-MAC chemotherapy (rifampicin, ethambutol, and clarithromycin) once these adverse effects have abated, for which the patient is being closely monitored.

Photograph and photomicrographs of the lung. a Photograph of a cross-sectional specimen in the resected lung showing a granuloma with caseating necrosis (arrow) and pleurisy (arrowhead). b Photomicrograph showing pleurisy over the visceral pleurae (circle; bar 500 μm), which revealed granulomatous infiltration. c-d Photomicrograph showing an epithelioid granuloma with necrosis and calcification (arrows) (C; bar 250 μm, D; bar 25 μm)

Discussion

To our knowledge, this is the first report regarding MAC-SPN presenting with persistent chest pain and induced by histologically confirmed pleurisy. Since Gribetz et al. reported the first case series in 1981 [], 45 cases of MAC-SPN have been reported: 33 from East Asia [–] and 12 from the USA []. MAC-SPN generally affects middle-aged to elderly (median = 63 years; range: 37–81 years) men and women equally. The majority of the cases were diagnosed via chest imaging, and the patients were usually asymptomatic; however, respiratory symptoms, such as cough, sputum, and hemoptysis, were reported occasionally. In contrast, our patient was younger and had no respiratory symptoms aside from persistent chest pain, which was induced by histologically confirmed pleurisy without pleural effusion (so-called “dry pleurisy”) caused by M. avium. A report of MAC (not MAC-SPN) pleurisy in 16 cases with pleural effusion included a patient who was younger than the patient in the present case []. The factors for the onset of MAC-SPN are unknown. In the literature, only 7 cases were associated with underlying pulmonary disease (4 with old tuberculosis, 2 with lung cancer, and 1 with emphysema), and none of the patients were immunocompromised or had a family history of MAC lung disease. However, given that recent studies have suggested the importance of genetic or familial susceptibility to MAC lung disease [, ], further studies are warranted to assess MAC-SPN host factors.

In the present case, lung cancer and tuberculoma were included in the differential diagnosis of SPN prior to the definitive diagnosis of MAC-SPN. Distinguishing MAC from tuberculoma in cases involving an SPN is very difficult. In a report of 26 patients with tuberculoma and 15 patients with MAC-SPN [], 10 of the patients with MAC-SPN were initially diagnosed with tuberculoma and administered antituberculous medications. The patients with MAC-SPN were older and had higher maximum SUV in PET than the patients with tuberculoma. In 9 cases of nontuberculous mycobacterium (NTM) presenting as an SPN [–], the mean maximum SUV on FDG-PET was 8.6 (range: 4.4–13.2). Therefore, the maximum SUV in the present case (13.9) was higher than that observed in previous reports. Ruling out lung cancer should be undertaken with great care, as the coexistence of lung cancer and MAC pulmonary disease has been reported [, ]. FDG-PET is reportedly useful for evaluating disease activity and monitoring the therapeutic response in patients with NTM lung disease [], indicating that high activity of MAC-SPN could cause pleurisy, as observed in the present case.

Tmux mac command key. Nov 12, 2014  How to Use tmux on Mac: The Basics. If you have followed this kind of guide to setup iTerm2, Homebrew and ZSH, you only need to run the command brew install tmux. Homebrew is a package manager, ZSH is UNIX Shell; you should not get confused with Terminal Emulators and Terminal.

In the present case, surgical resection of MAC-SPN was performed, and we plan to initiate anti-MAC chemotherapy once the adverse effects have abated, although the significance of chemotherapy for MAC-SPN following surgical resection remains controversial. In the literature, of 45 patients with MAC lung disease presenting as an SPN, surgical resection was performed in 16 patients. Of the 14 patients who were administered anti-MAC chemotherapy after the surgical resection, none experienced recurrence; however, this was also true for the remaining 2 patients who were not administered anti-MAC chemotherapy [–, ]. Chemotherapy for MAC-SPN without surgical resection has also been reported as effective, with the size of the SPN decreasing in 9 of 10 patients undergoing anti-MAC chemotherapy []. In 15 patients with MAC-SPN, 5 did not undergo any treatment, and the size of the SPN decreased spontaneously in 3 patients, was unchanged in 1 patient, and increased in 1 patient. Anti-MAC chemotherapy was eventually initiated in 2 of these 5 patients []. Therefore, anti-MAC chemotherapy can be withheld until the size of an SPN increases, even without surgical therapy.

Conclusion

We report a case with MAC-SPN with high-intensity FDG uptake and histologically confirmed pleurisy. MAC should be considered in the differential diagnosis of an SPN, even for patients who experience persistent chest pain. Surgical resection with video-assisted thoracoscopic surgery is a reasonable approach to the diagnosis and treatment of MAC-SPN with possible malignancy, as MAC can be diagnosed using resected lung tissue culture with histological confirmation.

Consent

Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.

Acknowledgements

The authors thank Dr. Takuro Sakagami for testing the anti-interferon-γ autoantibodies.

Abbreviations

CTcomputed tomography
FDG18F-fluorodeoxyglucose
MACMycobacterium avium complex
NTMnontuberculous mycobacterium
PETpositron emission tomography
SUVstandard uptake value
SPNsolitary pulmonary nodule

Footnotes

Competing interests

The author(s) declare that they have no competing interests.

Authors’ contributions

TA and MI drafted the manuscript. TA, MH, IK, MK, HS, KE, YH, HS, IK, and KS contributed to the diagnosis and treatment. MI, HN, ST, NH, and TB reviewed the manuscript. All the authors approved the final version of the manuscript.

Contributor Information

Takanori Asakura, Email: moc.liamg@arukasa.ironakat.

Makoto Ishii, Email: pj.oiek.6z@iihsi.

Mizuha Haraguchi, Email: pj.en.ten-os.7fr@h-ahuzim.

Ikuo Kamiyama, Email: pj.en.ten-os.4cr@imak_i.

Mitsutomo Kohno, Email: pj.ca.oiek.niukuj.3991@onhok.

Hiroyuki Sakamaki, Email: moc.liamg@17ikamakas.

Classic Solitaire For Mac

Katsura Emoto, Email: pj.oiek.7a@otome.

Yuichiro Hayashi, Email: moc.liamg@27ihsayahorihciuy.

Hiroaki Sugiura, Email: pj.en.ten-os.omom@aruigush.

Ichiro Kawada, Email: pj.ro.alalp.laroc@korihci.

Kenzo Soejima, Email: pj.ca.oiek.dem.tenpc@amijeosk.

Ho Namkoong, Email: moc.liamg@nugumanuoh.

Sadatomo Tasaka, Email: pj.ca.oiek.dem.tenpc@akasat.

Naoki Hasegawa, Email: pj.oiek.8z@awagesah-n.

Tomoko Betsuyaku, Email: pj.oiek.5z@ukayustebt.

References

1. Gribetz AR, Damsker B, Bottone EJ, Kirschner PA, Teirstein AS. Solitary pulmonary nodules due to nontuberculous mycobacterial infection. Am J Med. 1981;70:39–43. doi: 10.1016/0002-9343(81)90409-5. [PubMed] [CrossRef] [Google Scholar]
2. Sawai T, Soda H, Kohno S. Mycobacterium intracellulare pulmonary infection which co-existed and mimicked lung cancer. Intern Med. 2008;47:459–62. doi: 10.2169/internalmedicine.47.0586. [PubMed] [CrossRef] [Google Scholar]
3. Kobashi Y, Fukuda M, Yoshida K, Miyashita N, Niki Y, Oka M. Four cases of pulmonary Mycobacterium avium intracellulare complex presenting as a solitary pulmonary nodule and a review of other cases in Japan. Respirology. 2006;11:317–21. doi: 10.1111/j.1440-1843.2006.00847.x. [PubMed] [CrossRef] [Google Scholar]
4. Kobashi Y, Yoshida K, Miyashita N, Niki Y, Matsushima T. Pulmonary Mycobacterium avium disease with a solitary pulmonary nodule requiring differentiation from recurrence of pulmonary adenocarcinoma. Intern Med. 2004;43:855–60. doi: 10.2169/internalmedicine.43.855. [PubMed] [CrossRef] [Google Scholar]
5. Kobashi Y, Fukuda M, Yoshida K, Miyashita N, Oka M. Pulmonary Mycobacterium intracellulare disease with a solitary pulmonary nodule detected at the onset of pneumothorax. J Infect Chemother. 2006;12:203–6. doi: 10.1007/s10156-006-0451-1. [PubMed] [CrossRef] [Google Scholar]
6. Inoue Y, Sawai T, Doi S, Ohno H, Izumikawa K, Yanagihara K, et al. Nontuberculous mycobacterial infections involving solitary pulmonary nodules. Nihon Kokyuki Gakkai Zasshi. 2007;45:655–60. [PubMed] [Google Scholar]
7. Kwon YS, Koh WJ, Chung MP, Kwon OJ, Lee NY, Cho EY, et al. Solitary pulmonary nodule due to Mycobacterium intracellulare: the first case in Korea. Yonsei Med J. 2007;48:127–30. doi: 10.3349/ymj.2007.48.1.127.[PMC free article] [PubMed] [CrossRef] [Google Scholar]
8. Hahm CR, Park HY, Jeon K, Um SW, Suh GY, Chung MP, et al. Solitary pulmonary nodules caused by Mycobacterium tuberculosis and Mycobacterium avium complex. Lung. 2010;188:25–31. doi: 10.1007/s00408-009-9203-1. [PubMed] [CrossRef] [Google Scholar]
9. Kawate E, Yamazaki M, Kohno T, Fujimori S, Takahashi H. Two cases with solitary pulmonary nodule due to non-tuberculous mycobacterial infection showing intense 18F-fluorodeoxyglucose uptake on positron emission tomography scan. Geriatr Gerontol Int. 2010;10:251–4. doi: 10.1111/j.1447-0594.2010.00619.x. [PubMed] [CrossRef] [Google Scholar]

Spider Solitaire For Mac

10. Lim J, Lyu J, Choi CM, Oh YM, Lee SD, Kim WS, et al. Non-tuberculous mycobacterial diseases presenting as solitary pulmonary nodules. Int J Tuberc Lung Dis. 2010;14:1635–40. [PubMed] [Google Scholar]
11. Shu CC, Lee LN, Wang JT, Chien YJ, Wang JY, Yu CJ. Non-tuberculous mycobacterial pleurisy: an 8-year single-centre experience in Taiwan. Int J Tuberc Lung Dis. 2010;14:635–41. [PubMed] [Google Scholar]
12. Bellamy R. Susceptibility to mycobacterial infections: the importance of host genetics. Genes Immun. 2003;4:4–11. doi: 10.1038/sj.gene.6363915. [PubMed] [CrossRef] [Google Scholar]

Solitaire For Mac Free Download

13. Szymanski EP, Leung JM, Fowler CJ, Haney C, Hsu AP, Chen F, et al. Pulmonary Nontuberculous Mycobacterial Infection. A Multisystem, Multigenic Disease. Am J Respir Crit Care Med. 2015;192:618–28. doi: 10.1164/rccm.201502-0387OC.[PMC free article] [PubMed] [CrossRef] [Google Scholar]
14. Tamura A, Hebisawa A, Sagara Y, Suzuki J, Masuda K, Nagai H, et al. Coexistence of lung cancer and active pulmonary mycobacteriosis. Kekkaku. 2005;80:413–9. [PubMed] [Google Scholar]

Solitaire For Macintosh

15. Demura Y, Tsuchida T, Uesaka D, Umeda Y, Morikawa M, Ameshima S, et al. Usefulness of 18F-fluorodeoxyglucose positron emission tomography for diagnosing disease activity and monitoring therapeutic response in patients with pulmonary mycobacteriosis. Eur J Nucl Med Mol Imaging. 2009;36:632–9. doi: 10.1007/s00259-008-1009-5. [PubMed] [CrossRef] [Google Scholar]

Full Deck Solitaire For Mac

Articles from Journal of Medical Case Reports are provided here courtesy of BioMed Central